Table 3.

Detection of biomarkers from proband urine

Characteristic	Reference	Result
	Range	Proband 1	Proband 2
Urinary albumin	< 150 mg/L	297.85 ± 23.23	527.98 ± 384.37
Urinary creatinine	–	8.91 ± 1.57	26.514
Total 24-h urinary protein	< 230 mg/24 h	414 ± 166.88 ↑	485 ± 190.92 ↑
Urinary albumin/urinary creatinine	0–30 mg/g	300.86 ± 42.18 ↑	363 ↑
Urinary α1-microglobulin	< 12 mg/L	27.08 ± 10.48 ↑	16.65 ± 8.25 ↑
Urinary β2-microglobulin	< 0.3 mg/L	0.18 ± 0.08	0.1 ± 0.25
Urinary transferrin	< 2 mg/L	21.60 ± 2.16 ↑	39.26 ± 31.52 ↑

The black arrows represent the increase of corresponding detection indicators