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. 2022 Sep 26;61(20):2165–2176. doi: 10.1021/acs.biochem.2c00349

Figure 5.

Figure 5

DJ-1 structures with cysteines in different oxidation states (PDB entries 1SOA, 4RKW, 4P34, and 2R1T), with the dimeric interface region (residues 38–70) colored green. The cysteines in the structure are shown in ball-and-stick representation labeled with their respective residue numbers. The regions enclosed in the dashed box containing Cys106 in different oxidation states (-SH, -SOH, and -SOOH) are enlarged in panels B–D. The positions associated with familial mutations are colored red on the cartoon representation with their residue numbers shown. Cys53 can undergo dopamine quinone conjugation (inset in the top right corner of panel A).