Figure 1.

Comparison between the (A) CAVS1 CG model and (B) CAVS2 CG model for cholesterol. In the CAVS1 and CAVS2 models, two C1T beads were respectively attached to the cholesterol ring to prevent the closer packing between cholesterol molecules, and the nonpolar tail of cholesterol was grouped into three beads (one C2P and two C3P beads). As for the cholesterol ring, four CG particles (one CIO, one C6R, and two C4R beads) were used for the CAVS1 model and seven CG particles (one CEO, one C3E, two C3P, and three C2P beads) for the CAVS2 model.