TABLE 4.
Most significant associations of the dose-response phenome-wide association study.
| Phenotype Description | Beta | SE | OR | Lower | Upper | P-value | N Cases | N Controls |
| Mood disorders | 0.204 | 0.009 | 1.226 | 1.225 | 1.227 | 2.00 × 10–110 | 3,592 | 7,319 |
| Depression | 0.201 | 0.009 | 1.223 | 1.222 | 1.224 | 1.30 × 10–104 | 3,410 | 7,319 |
| Major depressive disorder | 0.216 | 0.010 | 1.241 | 1.240 | 1.241 | 2.93 × 10–98 | 2,391 | 7,319 |
| Anxiety disorders | 0.179 | 0.009 | 1.196 | 1.196 | 1.197 | 1.42 × 10–97 | 4,490 | 7,319 |
| Anxiety disorder | 0.181 | 0.009 | 1.198 | 1.198 | 1.199 | 1.73 × 10–92 | 3,851 | 7,319 |
| Tobacco use disorder | 0.177 | 0.009 | 1.194 | 1.193 | 1.195 | 6.97 × 10–90 | 3,286 | 9,987 |
| Posttraumatic stress disorder | 0.386 | 0.021 | 1.472 | 1.470 | 1.474 | 1.30 × 10–76 | 333 | 7,319 |
| Schizophrenia/ psychotic disorders |
0.221 | 0.013 | 1.248 | 1.247 | 1.249 | 9.86 × 10–66 | 1,180 | 7,319 |
| Psychosis | 0.218 | 0.013 | 1.244 | 1.243 | 1.245 | 7.61 × 10–63 | 1,157 | 7,319 |
| Bipolar | 0.306 | 0.019 | 1.358 | 1.357 | 1.360 | 8.05 × 10–59 | 412 | 7,319 |
| Substance addiction and disorders | 0.241 | 0.015 | 1.273 | 1.272 | 1.274 | 8.68 × 10–59 | 714 | 9,987 |
| Generalized anxiety disorder | 0.195 | 0.013 | 1.216 | 1.215 | 1.217 | 1.70 × 10–54 | 1,261 | 7,319 |
| Other mental disorder | 0.148 | 0.012 | 1.159 | 1.159 | 1.160 | 4.61 × 10–37 | 1,692 | 7,319 |
| Morbid obesity | 0.129 | 0.010 | 1.138 | 1.137 | 1.139 | 2.15 × 10–35 | 1,908 | 8,629 |
| Sleep disorders | 0.108 | 0.009 | 1.115 | 1.114 | 1.115 | 4.10 × 10–34 | 3,253 | 9,410 |
| Nausea and vomiting | 0.105 | 0.009 | 1.111 | 1.110 | 1.112 | 4.43 × 10–34 | 2,953 | 10,772 |
| Alcohol-related disorders | 0.202 | 0.017 | 1.224 | 1.223 | 1.225 | 5.74 × 10–34 | 608 | 9,987 |
| Adjustment reaction | 0.165 | 0.014 | 1.179 | 1.178 | 1.180 | 8.34 × 10–33 | 1,068 | 7,319 |
| Obesity | 0.097 | 0.008 | 1.102 | 1.102 | 1.103 | 1.09 × 10–32 | 4,161 | 8,629 |
| Dysthymic disorder | 0.205 | 0.017 | 1.227 | 1.226 | 1.229 | 1.49 × 10–32 | 586 | 7,319 |
| Tooth Diseases | 0.161 | 0.014 | 1.175 | 1.174 | 1.176 | 1.65 × 10–32 | 958 | 12,230 |
| Overweight | 0.091 | 0.008 | 1.095 | 1.095 | 1.096 | 5.23 × 10–32 | 5,096 | 8,629 |
| Suicidal ideation or attempt | 0.322 | 0.027 | 1.381 | 1.378 | 1.383 | 8.06 × 10–32 | 175 | 7,319 |
| Insomnia | 0.115 | 0.010 | 1.122 | 1.122 | 1.123 | 1.83 × 10–31 | 2,420 | 9,410 |
| Sleep apnea | 0.119 | 0.010 | 1.126 | 1.125 | 1.127 | 2.48 × 10–30 | 2,403 | 9,410 |
| Shortness of breath | 0.112 | 0.010 | 1.119 | 1.118 | 1.119 | 4.63 × 10–30 | 2,866 | 6,945 |
| Esophagitis | 0.100 | 0.009 | 1.105 | 1.104 | 1.105 | 1.24 × 10–29 | 3,498 | 9,381 |
| Diseases of esophagus | 0.099 | 0.009 | 1.104 | 1.103 | 1.104 | 2.03 × 10–29 | 3,574 | 9,381 |
| GERD | 0.100 | 0.009 | 1.106 | 1.105 | 1.106 | 2.34 × 10–29 | 3,377 | 9,381 |
| Alcoholism | 0.207 | 0.019 | 1.230 | 1.229 | 1.231 | 1.41 × 10–28 | 457 | 9,987 |
| Suicidal ideation | 0.348 | 0.032 | 1.417 | 1.414 | 1.419 | 6.33 × 10–28 | 127 | 7,319 |
| Digestive symptoms | 0.097 | 0.009 | 1.102 | 1.101 | 1.102 | 4.52 × 10–27 | 3,055 | 9,069 |
| Back pain | 0.083 | 0.008 | 1.086 | 1.086 | 1.087 | 5.24 × 10–25 | 4,603 | 9,122 |
| Agoraphobia and Panic Disorder | 0.193 | 0.019 | 1.213 | 1.212 | 1.215 | 1.78 × 10–24 | 438 | 7,319 |
| Asthma | 0.096 | 0.009 | 1.101 | 1.100 | 1.101 | 2.06 × 10–24 | 2,579 | 9,078 |
| Chronic airway obstruction | 0.166 | 0.016 | 1.181 | 1.179 | 1.182 | 3.19 × 10–24 | 848 | 9,078 |
| Migraine | 0.100 | 0.010 | 1.105 | 1.105 | 1.106 | 2.18 × 10–23 | 1,987 | 10,586 |
| Chronic pain | 0.088 | 0.009 | 1.092 | 1.092 | 1.093 | 3.86 × 10–23 | 3,790 | 7,704 |
| Abdominal pain | 0.076 | 0.008 | 1.079 | 1.079 | 1.080 | 5.11 × 10–23 | 4,933 | 8,792 |
| Chronic pain syndrome | 0.204 | 0.021 | 1.226 | 1.224 | 1.227 | 5.77 × 10–23 | 349 | 11,946 |
| Neurological disorders | 0.126 | 0.013 | 1.134 | 1.133 | 1.135 | 1.24 × 10–22 | 1,150 | 12,224 |
| Electrolyte Disorders | 0.094 | 0.010 | 1.099 | 1.098 | 1.100 | 1.71 × 10–22 | 2,462 | 11,180 |
| Obstructive sleep apnea | 0.111 | 0.011 | 1.117 | 1.116 | 1.118 | 2.25 × 10–22 | 1,917 | 9,410 |
| Constipation | 0.116 | 0.012 | 1.122 | 1.124 | 1.123 | 4.83 × 10–22 | 1,282 | 12,443 |
| Opiates affecting therapy | 0.122 | 0.013 | 1.128 | 1.130 | 1.129 | 6.64 × 10–22 | 1,218 | 9,902 |
| Other dyspnea | 0.098 | 0.010 | 1.102 | 1.104 | 1.103 | 1.52 × 10–21 | 2,709 | 6,945 |
| Heartburn | 0.101 | 0.011 | 1.106 | 1.107 | 1.106 | 7.39 × 10–21 | 1,981 | 9,381 |
This table shows the strongest statistically significant dose-response associations with ACEs and phenotypes (p-values p < 1 × 10–20).