Figure 4. Correlation between serum metabolites and the clinical indicators of early NAFLD.
The distance correlation matrix plots displaying the partial Spearman’s correlation among the 59 serum differential metabolites and 11 clinical indicators of early NAFLD patients. Positive values (red) indicate positive correlations. Negative values (blue) indicate inverse correlations. Solid lines represent that P≤0.01. Dotted lines represent that 0.01<P≤0.05. Intensity of shading in circles is proportional to the magnitude of the association; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; FPG, fasting plasma glucose; GGT, γ-glutamyl transferase; HDL, high-density lipoprotein; NAFLD, nonalcoholic fatty liver disease patients; TC, total cholesterol; TG, triglycerides.