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. Author manuscript; available in PMC: 2022 Oct 20.
Published in final edited form as: Toxicol Appl Pharmacol. 2022 Aug 9;452:116193. doi: 10.1016/j.taap.2022.116193

Fig. 2.

Fig. 2.

AsIII binds to and displaces zinc from the GATA-2 protein. Primary mouse bone marrow HPCs were treated with 0 or 500 nM AsIII for 48 h. GATA-2 was purified from whole cell lysates by IP with a specific GATA-2 antibody. Following IP, and arsenic and zinc content in purified GATA-2 was measured by ICP-MS. (A) Arsenic (As) binds to the GATA-2 protein. (B) Loss of zinc (Zn) from the GATA-2 protein following AsIII exposure. Data were normalized relative to the control group and expressed as mean ± SD, n = 3–4/group, *p < 0.05, **p < 0.01 in Student’s t-test compared to untreated control.