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EC50 values of chicken ACTH1-39 and α-MSH in activating cAMP/PKA signaling pathways in CHO cells expressing chicken MC5R.
| EC50 (nM) | MC5R | MC5R + MRAP1 | MC5R + MRAP2 |
|---|---|---|---|
| ACTH1-39 | 5.91 ± 1.18 | 2.12 ± 0.37 | 3.19 ± 1.09 |
| α-MSH | 4.23 ± 0.83 | 7.85 ± 1.58 | 44.20 ± 10.21 a |
Results were expressed as the mean ± SEM, of at least three independent experiments.
Significantly different from the parameter of MC5R, p < 0.01.
