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. Author manuscript; available in PMC: 2022 Oct 20.
Published in final edited form as: Eur Cell Mater. 2022 Apr 5;43:130–152. doi: 10.22203/eCM.v043a11

Fig. 5. Potential cell-level regulators of enzymatic crosslinking in tendon.

Fig. 5.

Enzymatic crosslinking, mediated by LOX, may be regulated by (a) mechanoresponsive signaling pathways, such as the calcium ion channel PIEZO1, (b) signaling through the sex hormone estrogen, (c) TGFβ family, (d) hypoxia-induced HIF-1α signaling, and (e) intracellular and extracellular collagen interactions with glycoproteins including fibromodulin and TSP-1.