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. 2022 Jun 11;1(4):682–697. doi: 10.1016/j.gastha.2022.02.007

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Eicosanoid synthase expression in human PanIN and PDAC. (A) Boxplots comparing expression (log2 (TPM + 1)) of microdissected stroma and epithelium from PanIN (n = 26) and PDAC (n = 197 epithelium, 124 stroma). ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001. (B) Qualitative summary describing relative localization of terminal eicosanoid synthases in either the tumor epithelium or stroma. (C) Summary schematic describing a switch in prostaglandin synthase expression in the epithelium transitioning from PanIN to PDAC.