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. 2022 Jun 11;1(4):682–697. doi: 10.1016/j.gastha.2022.02.007

Figure 7.

Figure 7

Localization and survival benefit for select eicosanoid synthases in human PDAC. (A) Quantification of scored IHC for PTGES, PTGIS, or TBXAS1 from 22 patients encompassing normal, PanIN-, and PDAC-associated stroma and epithelium as well as both myxoid and compact fibrosis. (B) Representative IHC images. Scale bar, 100 μm. (C) Survival curves for total PTGES, PTGIS, or TBXAS1 expression generated from the TCGA database, representing 150 PDAC patients. The top and bottom 38 patients are shown. Survival curves for (D) total (epithelial and stromal expression combined where both high means high expression in both compartments) or (E) epithelium-specific PTGES, PTGIS, or TBXAS1 expression generated from the Maurer et al data set representing 197 epithelial samples and 124 stromal samples from PDAC patients. Quartiles reflect expression broken out into 25% of patients ranked by expression level of a given synthase.