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. 2022 Oct 3;13:954980. doi: 10.3389/fphar.2022.954980

FIGURE 2.

FIGURE 2

Genotype-dependent effects of XN on spontaneous alterations and activity in the Y-maze. (A). Hippocampus-dependent spontaneous alternation in the standard exposure experiment. (B). The number of arm entries in the Y-maze in the standard exposure experiment. In E4 mice, there was an effect of XN on activity levels. XN-treated E4 mice entered less arms than sex-matched E4 mice only on a HFD. Overall effect of XN: *p = 0.0004. (C). The number of arm entries in the Y-maze with sexes combined. XN-treated E4 mice entered less arms than sex-matched E4 mice only on a HFD. *p = 0.0004. (D). The percent of spontaneous alternations of E3 mice in the Y-maze with sexes combined in the extended exposure experiment. There was no effect of XN on spontaneous alternation of E3 mice in the extended exposure experiment. (E). The number of arm entries of E3 mice in the extended exposure experiment in the Y-maze with sexes combined. There was no effect of XN on arm entries of E3 mice. All graphs show the mean ± SEM.