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. 2022 Oct 3;13:954980. doi: 10.3389/fphar.2022.954980

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Copyright © 2022 Kundu, Holden, Paraiso, Sudhakar, McQuesten, Choi, Miranda, Maier, Bobe, Stevens and Raber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spatial learning and memory of female WT (A), E3 (B), E4 (C) and male WT (D), E3 (E), and E4 (F) in the water maze in the standard exposure experiment. The latency to locate the platform is shown. Mice were first trained in 4 sessions in which the platform location was visible, and subsequently they were trained to locate a hidden platform using extra-maze cues. In E4 mice, XN treatment improved performance during the visible platform training. *p < 0.05. (G,H) Spatial learning and memory of female (G) and male (H) E3 mice during the extended exposure experiment. There was a treatment by sex interaction during hidden platform training. XN improved performance of E3 males only (H). *p = 0.029. There was no significant effect of treatment on performance of females during the hidden platform training (G).