Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 3;13:954980. doi: 10.3389/fphar.2022.954980

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Kundu, Holden, Paraiso, Sudhakar, McQuesten, Choi, Miranda, Maier, Bobe, Stevens and Raber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

(A) Metabolic pathways affected by XN in the hippocampus of E3 males in the standard exposure experiment. (B) Differential effects of HFD in E3 and E4 males. Significantly altered pathways (p < 0.05) and with an Impact factor >0.3 are shown in (A,B). (C) The levels of spermidine, spermine, adenosine 3′,5′ diphosphate, arabitol, creatine, glyceric acid, and allantoin were higher in E3 than E4 HFD males. Significant metabolites were based on a volcano plot analysis. The volcano plot is a combination of fold change analysis and t-tests.