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. 2022 Oct 3;13:954980. doi: 10.3389/fphar.2022.954980

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Copyright © 2022 Kundu, Holden, Paraiso, Sudhakar, McQuesten, Choi, Miranda, Maier, Bobe, Stevens and Raber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hippocampal GABA and taurine levels. (A) In the standard exposure experiment, XN increased GABA levels in E3 males. *p = 0.0265. GABA levels were higher in E3 males than E3 females. **p = 0.0036. GABA levels were higher in E3 than E4 mice. ***p = 0.0002. (B) In the standard exposure experiment, taurine levels were higher in E3 males than females. **p = 0.0039. Taurine levels were also higher in E3 than E4 mice. ***p < 0.0001. (C) In the extended experiment, XN also increased GABA levels in E3 males. *p = 0.0265. (D) No effect of XN on taurine levels were seen in the extended experiment.