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. 2022 Oct 3;13:954980. doi: 10.3389/fphar.2022.954980

TABLE 3.

Association (Spearman correlations) between fear conditioning (1–4 refers to trial number) and sphingolipid group levels in the standard exposure experiment a .

Sphinganine Ceramides Sphingomyelin Glycos. Ceramides Total
Acquired Fear Response b :
Baseline freeze −0.113 −0.138 −0.073 −0.073 −0.104
Baseline motion −0.085 +0.151 +0.023 +0.106 +0.005
Tone freeze 1 −0.047 +0.069 +0.035 +0.228 −0.042
Tone freeze 2 −0.312 +0.147 +0.165 −0.028 −0.165
Tone freeze 3 −0.058 +0.274 +0.320* −0.035 +0.122
Tone freeze 4 −0.087 +0.112 +0.064 −0.144 −0.097
Shock motion 1 −0.037 +0.031 +0.185 −0.199 −0.090
Shock motion 2 +0.004 −0.030 +0.072 −0.310+ −0.057
Shock motion 3 +0.197 +0.050 +0.123 −0.199 +0.106
Shock motion 4 +0.132 −0.014 +0.098 −0.123 +0.049
Interval freeze 12 −0.198 +0.408** +0.269 +0.074 −0.003
Interval freeze 23 −0.352* +0.259 +0.134 −0.033 −0.230
Interval freeze 34 −0.375* +0.226 +0.147 −0.125 −0.226
Contextual Fear Response
Freeze (% time) +0.015 +0.088 +0.017 −0.041 −0.091
Cued Fear Response
Baseline Freeze +0.160 +0.304* +0.322* +0.071 +0.170
Tone Freeze +0.031 +0.256 +0.334* −0.029 +0.158
Baseline Freeze (%) +0.011 +0.446** +0.369* +0.318* +0.214
Tone Freeze (%) +0.091 +0.065 +0.237 −0.202 +0.153
a

Significant effects are indicated in bold.

b

Freeze is expressed in seconds per minute, freeze (%) refers to % of time frozen, motion is expressed in cm. 0.05 > P > 0.01, *; 0.01 > P > 0.001, **; P < 0.001, ***