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. Author manuscript; available in PMC: 2023 Mar 29.
Published in final edited form as: Annu Rev Virol. 2022 Jun 7;9(1):329–351. doi: 10.1146/annurev-virology-100220-113942

Figure 1.

Figure 1

Four principles involving GPCRs and their ligands by which viruses regulate their host. Viruses (a) induce or reduce expression of endogenous receptors, (b) express vGPCRs, (c) express chemokines, or (d) express chemokine-binding proteins to impact the host immune system. Abbreviations: EBI, Epstein-Barr virus–induced gene; EBV, Epstein-Barr virus; GPCR, G protein–coupled receptor; HCMV, human cytomegalovirus; HHV, human herpesvirus; HSV, herpes simplex virus; KSHV, Kaposi’s sarcoma-associated herpesvirus; vGPCR, viral G protein–coupled receptor; VZV, varicella-zoster virus. Figure adapted from images created with BioRender.com.