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. Author manuscript; available in PMC: 2023 Mar 29.
Published in final edited form as: Annu Rev Virol. 2022 Jun 7;9(1):329–351. doi: 10.1146/annurev-virology-100220-113942

Table 1.

Overview of human herpesviruses and their content of vGPCRs and viral chemokines

Herpesvirus Subfamily Primary disease(s) Disease
reactivation		 Latency/
latencies		 Viral
receptors		 Viral
chemokines
HSV1/HHV1 Alphaherpesvirinae: simplexvirus Often asymptomatic Oral herpes (cold sores)
Eczema herpiticum		 Oral herpes Trigeminal ganglia NA NA
HSV2/HHV2 Alphaherpesvirinae: simplexvirus Often asymptomatic
Genital herpes
Eczema herpiticum		 Genital herpes Dorsal root ganglia NA NA
VZV/HHV3 Alphaherpesvirinae: varicellovirus Chicken pox Zoster (shingles) Trigeminal and dorsal root ganglia NA NA
EBV/HHV4 Gammaherpesvirinae: lymphocryptovirus Infectious mononucleosis Often asymptomatic but potentially deadly B cells and epithelial cells BILF1 NA
HCMV/HHV5 Betaherpesvirinae: cytomegalovirus Often asymptomatic; rarely mononucleosis-like Often asymptomatic but potentially deadly CD34+ myeloid progenitors and CD14+ monocytes US27, US28, UL33, UL78 UL146, UL147
HHV6A/B Betaherpesvirinae: roseolovirus Exanthema subitum Usually asymptomatic; rarely hepatitis Monocytes and CD34+ stem cells U12, U51 U83A/B
HHV7 Betaherpesvirinae: roseolovirus Exanthema subitum Pityriasis rosea Usually asymptomatic; rarely hepatitis CD4+ T cells U12, U51 NA
KSHV/HHV8 Gammaherpesvirinae: rhadinovirus Usually asymptomatic; rarely fever and rash Usually asymptomatic, but potentially oncogenic B cells and endothelial cells ORF74 vCCL1, −2, −3

From left, the family and subfamily of the human herpesviruses are listed along with the diseases from primary infections and virus reactivation from latency and the main host cells during latency. The last two columns describe the viral GPCRs from each herpesvirus and the viral chemokines. Abbreviations: EBV, Epstein-Barr virus; GPCR, G protein–coupled receptor; HCMV, human cytomegalovirus; HHV, human herpesvirus; HSV, herpes simplex virus; KSHV, Kaposi’s sarcoma-associated herpesvirus; NA, not available; ORF, open reading frame; vGPCR, viral G protein–coupled receptor; VZV, varicella-zoster virus. Data obtained from References 6 and 7.