. Author manuscript; available in PMC: 2022 Oct 20.

Published in final edited form as: J Alzheimers Dis. 2022;85(4):1601–1619. doi: 10.3233/JAD-215084

Table 1.

The hAPP695^SW transgene results in imbalanced neuro-excitatory and neuro-inhibitory metabolites in Tg2576 versus WT hippocampal tissue

Neuro-excitatory metabolites	Log 2 (fold change)	p	Neuro-inhibitory metabolites	Log 2 (fold change)	p

Acetylcholine	0.22	0.023	ADENOSINE	−0.5	0.0073
GLUTAMIC ACID	0.048	0.018	Oleamide	−0.84	0.0056
N-ACETYL-L-ASPARTIC ACID	0.29	0.034	5-AMINOPENTANOATE	−0.26	0.018
METHACHOLINE	−0.64	0.35	Guanosine	0.088	0.42
5-hydroxyindolic acid	−0.0004	0.92	GABA	0.06	0.86
CYSTEINE	0.18	0.42	TAURINE	0.08	0.19