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. 2022 Oct 20;9:635. doi: 10.1038/s41597-022-01714-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Immune Signatures Transcriptomics Overview for young and old datasets. (a) Number of samples available for each data type, including transcriptomics (TX), hemagglutination inhibition assay (HAI), neutralizing antibody assay (NAB), and ELISA assays (ELISA). (b) Bar plot depicting the number of samples at each time point. The colors within each bar indicate the breakdown for each unique combination of pathogen and vaccine type. Day -7 and day 0 correspond to times pre-vaccination. (c) Box plot depicting the participant’s age distribution for each unique combination of pathogen and vaccine type. Note that Hepatitis A/B (Twinrix) cohort also received Diphtheria/Tetanus toxoid (Td) and Cholera inactivated vaccine at the same time (Dukoral). (d) Each area-proportional Euler diagram represents the total number of participants with corresponding data types.