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Establishment and functional analyses of CTLA-4-Ig. (a and b) Purified CTLA-4-Ig was confirmed via SDS-PAGE under nonreducing (a) and reducing (b) conditions. (c and d) Binding of CTLA-4-Ig to bovine CD80 (c) and bovine CD86 (d) was determine using flow cytometry. (e and f) CTLA-4-Ig inhibited the binding of bovine CD80 (e) or bovine CD86 (f) to bovine CD28. 2ME, 2-mercaptoethanol; isotype: purified bovine IgG1; control-Ig, purified rabbit IgG.
