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Suppression of IFN-γ production via CTLA-4-Ig. PBMCs from M. avium subsp. paratuberculosis-infected cattle (n = 6) were cultured with CTLA-4-Ig or Control-Ig (39) in the presence of J-PPD. IFN-γ production was measured using ELISA. P values were obtained using Steel-Dwass tests.
