FIG 4.

Protein interaction networks of proteins found in S-tEVs from L. monocytogenes-infected TSCs. The proteins of the S-tEVs from uninfected and L. monocytogenes-infected TSCs were determined by mass spectrometry. Protein interaction networks of the proteins identified in the S-tEVs from L. monocytogenes-infected TSCs were generated using the STRING program. The proteins involved in translation, microtubule cytoskeleton organization, and nucleosome core pathways are highlighted in blue, green, and red, respectively. Proteins that had twice the number of peptides identified in the L. monocytogenes-infected tEV samples versus the uninfected tEV samples were used for the analysis. The thickness of the line represents the confidence of the interaction between the proteins.