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. 2022 Oct 6;13:982786. doi: 10.3389/fimmu.2022.982786

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Copyright © 2022 Çetin, Studencka-Turski, Venz, Schormann, Junker, Hammer, Völker, Ebstein and Krüger

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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β5i/LMP7 deficient microglia exhibit more phagocytosis activity. (A–D) Phagocytosis activity was determined by the analysis of TAMRA-Aβ+ cell population in primary micrgolia. (A, B) Gating strategy of flow cytometry analysis of MACS isolated WT (A) and β5i/LMP7 KO (B) microglia incubated with 2µM TAMRA-labeled amyloid-beta (Aβ) toxic oligomers. (C) Bar graphs showing quantification of total CD45+ cells before Aβ treatment, total CD45+ cells after Aβ treatment, (D) Bar graphs showing quantification of total Aβ+ cells and Aβ+ cells in CD45+ cells in primary microglia. All data are given (n=3) by mean ± SEM; *: P < 0.05, **: P < 0.01.