Key resources table.

Reagent type (species) or resource	Designation	Source or reference	Identifiers	Additional information
Antibody	Anti-ß-ACTIN (Rabbit monoclonal)	Beyotime	Cat#AF5003	WB (1:200)
Antibody	Anti-NAGA (Rabbit polyclonal)	SinoBiological	Cat#13686-T24	WB (1:200)
Antibody	Anti-LYZ1 (Rabbit polyclonal)	Bioss Antibodies	Cat#bs-0816R	WB (1:200)
Antibody	Anti-NLRP3 (Rabbit polyclonal)	GenScript		polypeptide (aa29-42） WB (1:200)
Strain, strain background (Vibrio parahaemolyticus)	FITC-VP	Shantou University		2×106 particles/g
Chemical compound, drug	OptiPrep	Axis-shield	Cat# AS1114542
Chemical compound, drug	Trypan blue	Solarbio	Cat# C0040
Chemical compound, drug	FITC	Bioss	Cat# D-9801
Chemical compound, drug	Hoechst 33342 stain	Beyotime	Cat# C1028	100×
Peptide, recombinant protein	rEGFP	Huang et al., 2021 (https://doi.org/10.3389/fimmu.2021.707770)		recombinant plasmid, prokaryotic expression, purification
Peptide, recombinant protein	rCREG	Huang et al., 2021 (https://doi.org/10.3389/fimmu.2021.707770)		recombinant plasmid, prokaryotic expression, purification
Biological sample (Penaeus vannamei)	Haemolymph	Shantou local farms		Freshly isolated from Penaeus vannamei
Commercial assay, kit	RNAprep Pure Micro Kit	TIANGEN	Cat#DP420
Commercial assay, kit	First Strand cDNA Synthesis Kit	Beyotime	Cat#D7168M
Commercial assay, kit	3’Reagent Kits v3.1	10 X Genomics	1000268
Sequence-based reagent	CHIT1_F	This paper	qPCR primers	GTCGAAATTCCGGCCAAAGA
Sequence-based reagent	CHIT1_R	This paper	qPCR primers	GGCCCGTTCTTGTTTGACTT
Sequence-based reagent	Lyz1_F	This paper	qPCR primers	CAAGAACTGGGAGTGCATCG
Sequence-based reagent	Lyz1_R	This paper	qPCR primers	TCTGGAAGATGCCGTAGTCC
Sequence-based reagent	NAGA _F	This paper	qPCR primers	CTACGAGGACTACGGCAACT
Sequence-based reagent	NAGA _R	This paper	qPCR primers	CGAACTCTGGGTAGCCTTCA
Sequence-based reagent	EF-1α_F	This paper	qPCR primers	GTATTGGAACAGTGCCCGTG
Sequence-based reagent	EF-1α_R	This paper	qPCR primers	ACCAGGGACAGCCTCAGTAAG