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. 2022 Oct 19;221(12):e202203139. doi: 10.1083/jcb.202203139

Figure 9.

Figure 9.

Current working model: Vacuolar trafficking is organized as a “hub and spoke” type distribution system. CFS1 interacts with both ATG8 and VPS23A and mediates the formation of amphisomes—hybrid prevacuolar compartments that are formed by the fusion of multivesicular bodies and autophagosomes.