Table 1.
Baseline demographic and clinical characteristics.
| Factor | FFR ≤ 0.8 (n = 280) | FFR > 0.8 (n = 410) | t/χ2/Z | p |
|---|---|---|---|---|
| Age (years) | 57.84 ± 9.78 | 58.91 ± 8.99 | −1.034 | 0.302 |
| Male (n(%)) | 208 (74.3%) | 270 (65.9%) | 5.558 | 0.018 |
| BMI (kg/m2) | 25.79 ± 2.77 | 25.11 ± 2.71 | 2.238 | 0.026 |
| Hypertension (n(%)) | 159 (56.8%) | 212 (51.7%) | 1.726 | 0.189 |
| DM (n(%)) | 86 (30.7%) | 105 (25.6%) | 2.166 | 0.141 |
| Smoking (n(%)) | 88 (31.4%) | 124 (30.2%) | 0.110 | 0.740 |
| HR (bpm) | 69.85 ± 6.95 | 70.01 ± 6.38 | −0.224 | 0.823 |
| SBP (mmHg) | 129.02 ± 8.90 | 127.95 ± 6.98 | 1.139 | 0.256 |
| EF (%) | 64.82 ± 4.78 | 65.14 ± 4.14 | −0.650 | 0.516 |
| WBC (1012/L) | 6.30 (5.41,7.66) | 6.06 (5.05,7.05) | −1.932 | 0.053 |
| RBC (1012/L) | 4.63 ± 0.45 | 4.61 ± 0.42 | 0.517 | 0.605 |
| PLT (109/L) | 217.57 ± 45.27 | 220.31 ± 48.02 | −0.529 | 0.597 |
| MONO (109/L) | 0.34 (0.27,0.45) | 0.33 (0.25,0.42) | −1.660 | 0.097 |
| LYM (109/L) | 1.77 (1.42,2.15) | 1.77 (1.38,2.14) | −0.363 | 0.717 |
| NE (109/L) | 4.01 (3.25,5.02) | 3.71 (2.96,4.63) | −2.145 | 0.032 |
| HG (g/L) | 142.73 ± 14.67 | 141.38 ± 13.95 | 0.857 | 0.392 |
| HCT (%) | 41.20 ± 3.72 | 40.97 ± 3.61 | 0.568 | 0.570 |
| MCV (fl) | 89.04 ± 3.79 | 89.15 ± 4.17 | −0.233 | 0.816 |
| MCH (pg) | 30.85 ± 1.62 | 30.73 ± 1.60 | 0.704 | 0.482 |
| MCHC (g/L) | 346.18 ± 10.69 | 344.37 ± 10.16 | 1.563 | 0.119 |
| RDW (fl) | 42.19 ± 2.55 | 42.14 ± 2.51 | 0.168 | 0.867 |
| TG (mmol/L) | 1.40 (0.99,1.95) | 1.34 (0.93,1.81) | −1.161 | 0.246 |
| TC (mmol/L) | 4.07 (3.4,4.75) | 4.03 (3.43,4.90) | −0.023 | 0.981 |
| LDL-c (mmol/L) | 2.38 (1.73,2.97) | 2.34 (1.77,2.83) | −0.521 | 0.602 |
| HDL-c (mmol/L) | 1.04 (0.92,1.14) | 1.19 (1.00,1.39) | −6.006 | <0.001 |
| Glu (mmol/L) | 5.82 (5.27,6.81) | 5.6 (5.17,6.45) | −1.505 | 0.132 |
| HbA1c (mmol/L) | 5.9 (5.6,6.6) | 5.8 (5.4,6.5) | −1.384 | 0.166 |
| ALT(mmol/L) | 22 (16,33) | 21 (15,30) | −1.269 | 0.204 |
| AST (mmol/L) | 21.5 (18,26) | 21 (18,26) | −0.722 | 0.470 |
| TP (g/L) | 69.64 ± 5.48 | 69.31 ± 5.71 | 0.540 | 0.590 |
| ALB (g/L) | 43.41 ± 3.91 | 43.29 ± 3.95 | 0.275 | 0.783 |
| T-bil (μmol/L) | 13.2 (10.4,16.8) | 13.2 (10.5,16.5) | −0.026 | 0.979 |
| D-bil (μmol/L) | 2.74 (2.04,3.52) | 2.87 (2.13,3.79) | −0.338 | 0.735 |
| TBA (μmol/L) | 2.7 (1.4,4.5) | 2.2 (1.3,3.6) | −2.031 | 0.042 |
| ChE(KU/L) | 8.2 (7.4,9.3) | 8.3 (7.2,9.2) | −0.03 | 0.976 |
| GGT (U/L) | 26 (19,41) | 26 (18,39) | −0.818 | 0.413 |
| ALP (U/L) | 77 (62,90) | 78 (66,93) | −1.022 | 0.307 |
| Urea (mmol/L) | 5.2 (4.5,6.2) | 5.0 (4.3,5.8) | −2.070 | 0.038 |
| UA (μmol/L) | 366.7 (324.8,408.6) | 310.8 (277.1,358.8) | −7.113 | <0.001 |
| Cr (μmol/L) | 69.73 ± 13.20 | 65.34 ± 12.16 | 3.134 | 0.002 |
| Hcy (μmol/L) | 11.7 (9.3,15.8) | 11.9 (8.9,14.8) | −0.591 | 0.554 |
| CRP (mg/L) | 1.00 (0.50,2.08) | 0.85 (0.39,2.09) | −0.942 | 0.346 |
| UHR | 365.3 (314.6,422.6) | 268.8 (199.2,345.4) | −8.445 | <0.001 |
| FFR | 0.75 (0.70,0.78) | 0.87 (0.84,0.91) | −15.636 | <0.001 |
|
| ||||
| Angiography | ||||
| LM | 8 (2.9%) | 12 (2.9%) | 0.003 | 0.957 |
| LAD | 230 (82.1%) | 321 (78.3%) | 1.533 | 0.261 |
| LCX | 13 (4.6%) | 25 (6.1%) | 0.677 | 0.411 |
| RCA | 29 (10.4%) | 52 (12.7%) | 0.869 | 0.351 |
|
| ||||
| Medicine | ||||
| Aspirin (n(%)) | 270 (96.4%) | 387 (94.4%) | 1.518 | 0.218 |
| Statin (n(%)) | 255 (91.1%) | 368 (89.8%) | 0.328 | 0.567 |
| UA-lowering drugs (n(%)) | 16 (5.7%) | 18 (4.4%) | 0.623 | 0.430 |
| Beta blocker (n(%)) | 171 (61.1%) | 240 (58.5%) | 0.444 | 0.505 |
Abbreviations: BMI, body mass index; DM, diabetes mellitus; HR, heart rate; SBP, systolic blood pressure; EF, ejection fraction; WBC, white blood cell; RBC, red blood cell; PLT, platelet; MONO, monocyte; LYM, lymphocyte; NE, neutrophil; HG, hemoglobin; HCT, hematocrit; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular-hemoglobin concentration; MCV, mean corpuscular volume; RDW, red blood cell distribution width; TG, triglyceride; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; GLu, glucose; HbA1c, glycosylated hemoglobin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TP, total protein; ALB, albumin; T-Bil, total bilirubin, D-Bil, direct bilirubin; TBA, total bile acid; ChE, cholinesterase; GGT, glutamyl transpeptidase; ALP, alkaline phosphatase; UA, uric acid; Cr, creatinine; Hcy, homocysteine; CRP, C-reactive protein; LM, left main coronary artery; LAD, left anterior descending; LCX, left circumflex; RCA, right coronary artery.