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. 2022 Oct 21;11(1):292–305.e2. doi: 10.1016/j.jaip.2022.10.010

FIGURE 4.

FIGURE 4

The SARS-CoV-2–specific T-cell responses in 22q11.2DS patients before (6 months after the second dose) and after the third dose of mRNA (BNT162b2) vaccine. The cumulative IFN-γ–positive T-cell responses (total SFC against (A) complete WT Spike, (B) Omicron Spike, and (C) Omicron WT antigens) were evaluated by the T-SPOT Discovery SARS-CoV-2 ELISpot assay in 16 virus-naive participants. Statistical analyses were performed using the Wilcoxon matched-pairs signed-rank test. ∗∗P < .01; ∗∗∗P < .001. SFC, spot forming cells.