TABLE V.
Published reports of SARS-CoV-2 infection in 22q11.2DS
| Reference | Study design | Infection period considered | Sex/age | Comorbidities | COVID-19 symptoms | Hospital admission | Treatment | Outcome |
|---|---|---|---|---|---|---|---|---|
| 11 | Cross-sectional study (prevalence study) in June 2020 (end of first wave) including 65 moderate/severe IEIs patients | February 2020–Jun 2020 | M/17 y | Moderate/severe lymphopenia | Asymptomatic | No | No | Recovered |
| M/5 y | Moderate/severe lymphopenia | Mild (cough) | No | No | Recovered | |||
| 13 | Retrospective survey on 20 IEIs patients | February 2020–September 2020 | M/1.5 y | Bronchiectasis, low TRECs level, hypogammaglobulinemia | Asymptomatic | No | No | Recovered |
| 1 | A retrospective study was undertaken by a Web-based survey, including 94 patients with an underlying IEIs and infected by SARS-CoV-2 | March 2020–June 2020 | M/age group 0–2 y | Lung disease, tracheostomy with chronic ventilation | Severe (fever, dyspnea) | Yes | Convalescent plasma, oxygen support, NIV | Recovered |
| 18 | Case series of 60 individuals with IEIs National Registry, data collection proformas were sent to all U.K. pediatric and adult immunologists by email; 100 IEIs patients included | March 2020–July 2020 | M/>18y | NA | NA | Yes | NA | Recovered |
| 11 | Cross-sectional, multicenter study, involving 121 patients with IEIs | March 2020–December 2020 | M/0.7 y | Arterial hypertension, corrected congenital cardiopathy, hypogamma | Severe (fever, cough, dyspnea, severe diarrhea) | Yes (ICU) | NA | Recovered |
| 14 | Retrospective multicenter survey, 114 IEIs patients included | March 2020–April 2021 | F/13.8 y | Autoimmune hypothyroidism | Mild (Fever) | No | NA | Recovered |
| F/7 y | None | Mild (Fever) | No | NA | Recovered | |||
| F/23 y | CHD, allergy, bronchiectasis | Mild (running nose/sore throat) | No | NA | Recovered | |||
| F/1.5 y | History of interventricular defect and supraventricular paroxysmal tachycardia | Mild (fever) | No | NA | Recovered | |||
| F/17 y | Autoimmune thyroiditis, interventricular defect | Asymptomatic | No | NA | Recovered | |||
| F/9.25 y | Congenital heart disease (IAA, interatrial defect, interventricular defect) | Mild (fever, asthenia) | No | NA | Recovered | |||
| M/18.4 y | Autoimmune thyroiditis, mild thrombocytopenia, hyperbilirubinemia, vitamin D deficiency | Mild (runny nose) | No | NA | Recovered | |||
| F/11.5 y | Obesity, cognitive disability | Moderate (cough, headache, dyspnea, asthenia, nausea, arthralgia) | No | NA | Recovered | |||
| M/10.6 y | Left aortic arch, developmental delay | NA | No | NA | Recovered | |||
| M/1.6 y | Hypoparathyroidism, hypocalcemia, congenital hypothyroidism, bicuspid aorta | Asymptomatic | No | NA | Recovered | |||
| F/15.2 y | Hyperthyroidism, intellectual disability, congenital heart disease | NA | No | NA | Recovered | |||
| M/1 y | Minimal left to right interatrial shunt, nephrocalcinosis, hypoparathyroidism, areas of parenchymal lung consolidation, hypogammaglobulinemia | Severe (fever) | Yes | NA | Recovered | |||
| 3 | National Registry, data collection proformas were sent and 310 patients included | March 2020–July 2021 | Two males (18 and 21 y) | NA | Severe course (1 patient) | Yes (1) | NA | Recovered |
| 10 | Cross-sectional, multicenter study involving 99 IEIs patients | June 2020–June 2021 | M/1.5 y | NA | Mild (anxiety, bradycardia) | NA | NA | Recovered |
| 12 | Case report | NA (published on February 2021) | F/12 y | Hypogammaglobulinemia, T-cell lymphocytopenia, congenital heart disease, and VP shunt | Mild (headache, emesis) | NA | No | Recovered |
| NA (published on February 2021) | M/13 y | Obesity, congenital heart disease, low IgM | Asymptomatic | NA | NA | Recovered | ||
| 15 | Multinational survey on 152 patients with 22q11.2DS | July 2021–December 2021 | 25 patients, (range 2–36 y) | Overweight 21%, immunoglobulin infusions 4%, previous heart surgery 43%, hypertension 4%, psychiatric problems 11%, arthritis 11%, asthma 29% | Fatigue (63%), headache (54%), cough (51%), rhinorrhea (45%) | 1 of 25 hospitalized for 1 d | None | 25 of 25 recovered |
IAA, Interrupted aortic arch; ICU, intensive care unit; IEIs, inborn errors of immunity; NA, not available; NIV, noninvasive ventilation; TRECs, T-cell receptor excision circles; VP, ventriculoperitoneal shunt.