Fig. 3.

CYP-inhibition enhances the hepatotoxicity of ochratoxin A (OTA). A Macroscopic appearance of livers 24 h after administration of OTA (7.5 mg/kg; i.v.) with and without ABT (150 mg/kg, gavage; administered 2 h before OTA) compared to vehicle (PBS) or ABT controls. B Plasma activities of liver enzymes 24 h after OTA administration with and without ABT compared to vehicle or ABT controls; *p value ≤ 0.05, **p value ≤ 0.01 Tukey’s multiple comparisons test; n = 5 mice per group. C Histological appearance in H&E-stained tissue sections; scale bars: 50 µm