Table 1.

List of identified proteins in Hakai interactome analysis.

N	Accession number	Gene code	Protein name	Biological role
1	Q9Z1X4	ILF3	Interleukin enhancer-binding factor 3	Transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2
2	Q16630	CPSF6	Cleavage and polyadenylation specificity factor subunit 6	Subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing
3	O43809	NUDT21	Cleavage and polyadenylation specificity factor subunit 5	Subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing
4	Q92841	DDX17	ATP-dependent RNA helicase DDX17	RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure
5	P17844	DDX5	ATP-dependent RNA helicase DDX5	RNA helicases. This protein is involved in pathways that include the alteration of RNA structures
6	Q07955	SRSF1	Serine/arginine-rich splicing factor 1	Arginine/serine-rich splicing factor protein family
7	Q16658	FSCN1	Fascin	Member of the fascin family of actin-binding proteins
8	P18206	VCL	Vinculin	Cytoskeletal protein associated with cell–cell and cell–matrix junctions
9	Q2KJG3	NARS	Asparagine tRNA ligase	Asparaginyl-tRNA synthetase
10	Q07666	KHDRBS1	KH domain-containing, RNA-binding, signal transductionassociated protein 1	Member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family
11	P26640	VARS	Valine tRNA ligase	Valyl-tRNA synthetase
12	O00571	DDX3X	ATP-dependent RNA helicase DDX3X	ATP-dependent RNA helicase
13	P40939	HADHA	Trifunctional enzyme subunit alpha	Catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids
14	P49327	FASN	Fatty acid synthase	Catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids
15	P53396	ACLY	ATP-citrate synthase	Primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues
16	Q16822	PCK2	Phosphoenolpyruvate carboxykinase	Mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate
17	Q13263	TRIM28	Transcription intermediary factor 1-beta	Gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors
18	P48643	CCT5	T-complex protein 1 subunit epsilon	Molecular chaperone that is a member of the chaperonin containing TCP1 complex
19	Q16543	CDC37	Hsp90 co-chaperone	Molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90
20	P78527	PRKDC	DNA-dependent protein kinase catalytic subunit	Catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination
21	P54886	ALDH18A1	Delta-1-pyrroline-5-carboxylate synthase	Catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine
22	O15371	EIF3D	Eukaryotic translation initiation factor 3 subunit D	The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state
23	P26373	RPL13	60S ribosomal protein L13	This gene encodes a ribosomal protein that is a component of the 60S subunit
24	Q02878	RPL6	60S ribosomal protein L6	This gene encodes a protein component of the 60S ribosomal subunit
25	Q07020	RPL18	60S ribosomal protein L18	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit
26	P60842	EIF4A1	Eukaryotic initiation factor 4A-I	Eukaryotic translation initiation factor 4A1