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. 2022 Oct 20;8:136. doi: 10.1038/s41531-022-00388-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — a List of peptides used to search the Uniprot database to identify putative proteins that could cross-react against antibodies raised against the known aSyn phosphorylated residues highlighted in bold at the middle of each sequence. The number of candidate hits retrieved for human, mouse, or common to both organisms is indicated for each peptide. The asterisk (*) present in the last sequence indicates the C-terminal residue. b Sequence alignment of the region around human aSyn pS129 and Neurofilament light polypeptide (NFL) pS472, which is known to cross-react with antibodies raised against pS129-aSyn. c Sequence alignment of the region around human aSyn pY133 and Actin-binding LIM protein 1 pY439, illustrating the high level of similarity. d List of the top ten candidate proteins that can cross-react with pS129 antibody.