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. 2022 Oct 20;13:6221. doi: 10.1038/s41467-022-33785-w

Fig. 1. Individual transcriptional gene regulation networks for Rheumatoid Arthritis Fibroblast-like Synoviocytes allow for cell line stratification based on global TF regulatory differences.

Fig. 1

a Construction of cell line specific global transcriptional gene regulation networks using the Taiji Integrative Pipeline with RNA-seq and ATAC-seq data. Ranking of TFs using Personalized PageRank (PPR). b Cell line stratification into two clusters (CL1 and CL2) based on PPR. Hierarchical clustering using z-score(PPR) of top 100 TFs. c Top ranked TFs from a statistical power analysis of their regulatees and absolute change in PPR between CL1 and CL2. CL1- and CL2-specific TF “playlists”. Barplots of z-score(PPR) for top ranked cluster-specific TFs. Source data are provided as a Source Data file.