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. 2022 Oct 20;13:6212. doi: 10.1038/s41467-022-33951-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Western blot analysis of FLAG-FLOT1/FLOT2 in early endosome-enriched fractions (SPIONs) and intact endosome-IP fractions (n = 1). b Data-independent acquisition (DIA)-based protein abundance fold-change ratios of SPIONs/SPIONs+IP fractions (n = 3, biologically independent samples over three independent experiments). Significant differentially regulated proteins are indicated (cut-offs: q-value: <0.05, fold change: >1.5). c STRING-based PPI analysis of selected protein categories overrepresented in the SPIONs+IP fraction. Node size corresponds to the protein abundance and line thickness to the PPI confidence score. SPIONs superparamagnetic iron oxide nanoparticles, IP immunoprecipitation, IN input, SN supernatant, FT flow through, WA wash, EL eluate, PPI protein–protein interaction. Source data are provided as a Source Data file.