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. 2022 Oct 20;12:17553. doi: 10.1038/s41598-022-22377-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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High expression of TRKB in PGCs. (a) Representative H&E and TRKB staining images of tumor tissues from patients with PGC. Arrowheads indicate ductal epithelial cells with faint expression of TRKB. Scale bars, 100 μm. (b) TRKB expression levels in each type of PGC. Positivity and intensity of TRKB staining in cancer cells were analyzed using inForm and Spotfire software. TRKB expression levels were classified into three levels (staining intensity: < 0.05, level 1; 0.05–0.75, level 2; > 0.75, level 3) and divided into two groups: low (levels 1 and 2) and high (level 3).