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. 2022 Oct 13;239(11):3731–3741. doi: 10.1007/s00213-022-06248-9

Table 2.

Bonferroni-corrected pairwise comparisons between treatment conditions on mean state anxiety (VAS) at each level of baseline state and trait anxiety (low, medium and high)

Baseline state anxiety
Low Medium High
Mean VAS Mean difference p 95% CI Mean difference p 95% CI Mean difference p 95% CI
  CBD-PLA  − 0.22  > 0.99  − 0.92, 0.48 0.28  > 0.99  − 0.20, 0.77 0.79 0.11 0.09, 1.49
  THC/CBD-PLA  − 0.13  > 0.99  − 0.86, 0.60 0.84  <0.01* 0.34, 1.34 1.81  <0.01* 1.08, 2.55
  THC-PLA 1.53  <0.01* 0.88, 2.18 1.59  <0.01* 1.09, 2.09 1.65  <0.01* 0.99, 2.31
  THC-THC/CBD 1.66  <0.01* 0.99, 2.33 0.75 0.02* 0.24, 1.26  − 0.17  > 0.99  − 0.83, 0.50
Trait anxiety
Low Medium High
Mean VAS Mean difference p 95% CI Mean difference p 95% CI Mean difference p 95% CI
  CBD-PLA  − 0.34  > 0.99  − 1.03, 0.36 0.27  > 0.99  − 0.30, 0.84 0.88 0.06 0.17, 1.58
  THC/CBD-PLA 0.62 0.35  − 0.09, 1.33 0.96  <0.01* 0.36, 1.56 1.30  <0.01* 0.50, 2.10
  THC-PLA 1.63  <0.01* 0.93, 2.32 1.66  <0.01* 1.07, 2.24 1.69 <0.01* 0.96, 2.42
  THC-THC/CBD 1.01 0.02* 0.29, 1.72 0.70 0.10 0.89, 1.31 0.39  > 0.99  − 0.43, 1.20

VAS, visual analogue scale; CBD, cannabidiol; THC, delta-9-tetrahydrocannabinol; PLA, placebo

* indicates significant difference after Bonferroni correction