Table 3.

Expected concentration ranges from approved doses based on our findings (C/D ratios) and based on ratios from TDM Guidelines

Administered Dose [mg/day]	Expected ARI BL [ng/ml] based on C/D ratio 13.82	Dose-related range based on TDM Guidelines 11.72	Expected ARI + D-ARI BL [ng/ml] based on C/D ratio 18.18	Dose-related range based on TDM Guidelines 16.45
5	69.1 [62.0, 76.3]	58.6 [41.8–76.5]	90.9 [83.21, 98.7]	82.3 [56.0–109.5]
10	138.2 [123.9, 152.5]	117.2 [81.5–152.9]	181.8 [166.3, 197.3]	164.5 [111.9–218.9]
20	276.4 [247.8, 305]	234.4 [163.0–305.8]	363.6 [332.6, 394.6]	329 [223.8–437.8]
30	414.6 [371.7, 457.5]	351.6 [244.5–458.7]	545.4 [498.9, 591.9]	493.5 [335.7–656.7]