Table 1.
Patient and eye characteristics.
| AQP4-IgG+ | MOG-IgG+ | MS | HC | AQP4-IgG+ versus MOG-IgG+ | AQP4-IgG+ versus MS | AQP4-IgG+ versus HC | ||
|---|---|---|---|---|---|---|---|---|
| Subjects | n | 28 | 14 | 29 | 14 | |||
| Sex Female | N (%) | 26 (92.9%) | 7 (50%) | 21 (72.4%) | 10 (71.4%) | < 0.01 | 0.08 | 0.16 |
| Age [years] | Median [Range] | 49.5 [20–69] | 46.0 [21–59] | 39.4 [25–64] | 41.7 [24–68] | 0.52 | 0.01 | 0.43 |
| EDSS | Median [Range] | 3.75 [0.00–6.50] | 2.50 [1.00–6.00] | 2.00 [0.00–4.50] | – | 0.06 | < 0.01 | – |
| Visual FS | Median [Range] | 1.00 [0.00–6.00] | 0.00 [0.00–3.00] | 0.00 [0.00–5.00] | 0.07 | 0.01 | ||
| Eyes | N | 54 | 26 | 58 | 28 (−) | |||
| ON+ eyes | NON | 23 | 15 | 24 | ||||
|
ON History [Patients: NON/ON unilateral/ON bilateral] |
NNON/NuniON/NbilON | 12/9/7 | 4/5/5 | 10/14/5 | – | |||
| No. of ON (by ON-eye) | Median [Range] | 2 [1–8] | 2 [1–5] | 1 [1, 2] | – | 0.3 | 0.02 | – |
| Years since first ON (by eye) | Median [Range] | 6.9 [0.8–28.1] | 6.3 [0.8–42.6] | 6.5 [0.6–43.0] | – | 0.48 | 0.77 | – |
| Years since last ON (by eye) | Median [Range] | 4.7 [0.3–28.1] | 4.4 [0.3–39.6] | 6.5 [0.3–43.0] | – | 0.95 | 0.24 | – |
AQP4-IgG+ aquaporin-4 antibody seropositive patients, MOG-IgG+ myelin-oligodendrocyte-glycoprotein antibody seropositive patients, MS multiple sclerosis, HC healthy control, SD standard deviation, EDSS expanded disability status scale, FS functional system, ON optic neuritis.
P-values from Fischer´s Exact Test (sex ratio) or Mann–Whitney-U test (all other items); statistically significant results are printed in bold.