Table 3.

Structure–function associations for pRNFL and GCIP below 60 µm.

	AQP4-IgG+		MOG-IgG+		MS		Interaction AQP4-IgG+ versus MOG-IgG+		Interaction AQP4-IgG+ versus MS
pRNFL [µm]	Beta (SE)	p-value	Beta (SE)	p-value	Beta (SE)	p-value	Beta (SE)	p-value	Beta (SE)	p-value
HCVA [logMAR]	− 0.039 (0.007)	< 0.001	− 0.007 (0.003)	0.02	–	–	0.033 (0.008)	< 0.001	–
LCVA [logMAR]	− 0.044 (0.008)	< 0.001	− 0.046 (0.009)	< 0.001	–	–	− 0.002 (0.012)	0.89	–	–
MD [dB]	0.762 (0.097)	< 0.001	0.449 (0.063)	< 0.001	–	–	− 0.317 (0.129)	0.017	–	–

	AQP4-IgG+		MOG-IgG+		MS		Interaction AQP4-IgG+ versus MOG-IgG+		Interaction AQP4-IgG+ versus MS
GCIP [µm]	Beta (SE)	p-value	Beta (SE)	p-value	Beta (SE)	p-value	Beta (SE)	p-value	Beta (SE)	p-value
HCVA [logMAR]	− 0.037 (0.009)	< 0.001	− 0.011 (0.004)	0.003	− 0.042 (0.007)	< 0.001	0.025 (0.012)	0.04	− 0.010 (0.012)	0.44
LCVA [logMAR]	− 0.065 (0.010)	< 0.001	− 0.068 (0.012)	< 0.001	− 0.041 (0.010)	< 0.001	0.004 (0.016)	0.81	0.023 (0.014)	0.10
MD [dB]	0.835 (0.151)	< 0.001	0.571 (0.111)	< 0.001	0.515 (0.106)	< 0.001	− 0.270 (0.224)	0.23	− 0.302 (0.200)	0.13

Association between different measures of visual function and pRNFL- and GCIP-thickness respectively in a mixed linear spline model of NMOSD, MOGAD and MS eyes as well as interaction effects between the patient groups; all values are only from the sloped part of the spline for pRNFL and GCIP thickness values lower than 60 µm respectively (Fig. 2). No associations between pRNFL and visual function are provided for MS-eyes as there were not enough eyes below the 60 µm cutoff.

AQP4-IgG+ aquaporin-4 antibody positive NMOSD, MOG-IgG+ myelin-oligodendrocyte-glycoprotein associated disorder, MS multiple sclerosis, SE standard error, HCVA high contrast visual acuity, LCVA low contrast visual acuity, MD mean deviation, pRNFL peripapillary retinal nerve fiber layer, GCIP combined ganglion cell and inner plexiform layer.

Significant values are in bold.