Table 3.
Multivariable Logistic Regression Results for Association of Platelet Aggregation and TEG values at 24h with Development of VTE
| ADP Stimulated PA, 24hr | Odds Ratio | CI-Low | CI-High | P-Value |
|---|---|---|---|---|
| ADP PA, (per 10 AUC units) | 0.86 | 0.55 | 1.34 | 0.51 |
| Length of Stay (days) | 1.09 | 1.02 | 1.17 | 0.01 |
| Initiation of chemoprophylaxis within 72 hours | 0.27 | 0.08 | 0.86 | 0.03 |
| Platelet count (24 hours) | 0.99 | 0.98 | 1.01 | 0.35 |
| Injury Severity Score | 1.02 | 0.97 | 1.07 | 0.43 |
| Shock Index | 1.46 | 0.27 | 7.96 | 0.66 |
| Transfused in initial 24 hours | 1.21 | 0.23 | 6.44 | 0.82 |
| Area under ROC curve=0.84 | ||||
| Collagen Stimulated PA, 24h | Odds Ratio | CI-Low | CI-High | P-Value |
| Collagen PA, (per 10 AUC units) | 0.63 | 0.40 | 1.00 | 0.05 |
| Length of Stay (days) | 1.10 | 1.02 | 1.17 | 0.01 |
| Initiation of chemoprophylaxis within 72 hours | 0.40 | 0.12 | 1.30 | 0.13 |
| Platelet count (24 hours) | 1.00 | 0.98 | 1.01 | 0.86 |
| Injury Severity Score | 1.02 | 0.97 | 1.08 | 0.40 |
| Shock Index | 0.55 | 0.09 | 3.51 | 0.52 |
| Transfused in initial 24 hours | 1.55 | 0.26 | 9.37 | 0.63 |
| Area under ROC curve=0.84 | ||||
| Thrombin stimulated PA, 24 hours | Odds Ratio | CI-Low | CI-High | P-Value |
| Thrombin PA, (per 10 AUC units) | 0.91 | 0.68 | 1.23 | 0.55 |
| Length of Stay (days) | 1.11 | 1.03 | 1.19 | 0.01 |
| Initiation of chemoprophylaxis within 72 hours | 0.25 | 0.08 | 0.84 | 0.02 |
| Platelet count (24 hours) | 0.99 | 0.98 | 1.01 | 0.50 |
| Injury Severity Score | 1.03 | 0.98 | 1.09 | 0.27 |
| Shock Index | 1.59 | 0.29 | 8.75 | 0.59 |
| Transfused in initial 24 hours | 0.99 | 0.18 | 5.43 | 0.99 |
| Area under ROC curve=0.84 | ||||
| Delta-ADP presentation to 24 hours | Odds Ratio | CI-Low | CI-High | P-Value |
| Delta ADP, (per 10u) | 1.31 | 1.03 | 1.65 | 0.03 |
| Length of Stay (days) | 1.10 | 1.02 | 1.18 | 0.01 |
| Initiation of chemoprophylaxis within 72 hours | 0.45 | 0.13 | 1.54 | 0.20 |
| Platelet count (24 hours) | 0.99 | 0.97 | 1.00 | 0.15 |
| Injury Severity Score | 1.04 | 0.98 | 1.09 | 0.19 |
| Shock Index | 0.80 | 0.11 | 5.88 | 0.83 |
| Transfused in initial 24 hours | 0.89 | 0.16 | 5.10 | 0.90 |
| Area under ROC curve=0.86 | ||||
| Delta-Collagen presentation to 24 hours | Odds Ratio | CI-Low | CI-High | P-Value |
| Delta Collagen, (per 10u) | 1.36 | 1.07 | 1.73 | 0.01 |
| Length of Stay (days) | 1.10 | 1.02 | 1.18 | 0.01 |
| Initiation of chemoprophylaxis within 72 hours | 0.35 | 0.10 | 1.20 | 0.10 |
| Platelet count (24 hours) | 0.99 | 0.98 | 1.01 | 0.46 |
| Injury Severity Score | 1.04 | 0.98 | 1.10 | 0.21 |
| Shock Index | 0.82 | 0.10 | 6.50 | 0.85 |
| Transfused in initial 24 hours | 1.16 | 0.20 | 6.72 | 0.87 |
| Area under ROC curve=0.85 | ||||
| Delta-Thrombin, presentation to 24 hours | Odds Ratio | CI-Low | CI-High | P-Value |
| Delta- Thrombin, (per 10u) | 1.41 | 1.11 | 1.78 | <0.01 |
| Length of Stay (days) | 1.13 | 1.05 | 1.22 | <0.01 |
| Initiation of chemoprophylaxis within 72 hours | 0.18 | 0.04 | 0.72 | 0.02 |
| Platelet count (24 hours) | 0.99 | 0.98 | 1.01 | 0.23 |
| Injury Severity Score | 1.04 | 0.97 | 1.11 | 0.23 |
| Shock Index | 1.21 | 0.18 | 8.11 | 0.84 |
| Transfused in initial 24 hours | 0.55 | 0.08 | 3.67 | 0.53 |
| Area under ROC curve=0.88 | ||||
| Clot Strength at 24 hours | Odds Ratio | CI-Low | CI-High | P-Value |
| Clot strength, (mm) | 1.03 | 0.91 | 1.18 | 0.62 |
| Length of Stay (days) | 1.17 | 1.05 | 1.30 | <0.01 |
| Initiation of chemoprophylaxis within 72 hours | 0.31 | 0.09 | 1.07 | 0.06 |
| Injury Severity Score | 1.03 | 0.97 | 1.09 | 0.31 |
| Shock Index | 1.40 | 0.24 | 8.25 | 0.71 |
| Transfused in initial 24 hours | 2.97 | 0.49 | 17.88 | 0.23 |
| Area under ROC curve=0.84 | ||||
| Clot Lysis at 24 hours | Odds Ratio | CI-Low | CI-High | P-Value |
| CK-LY30, (%) | 2.49 | 1.14 | 5.49 | 0.02 |
| Length of Stay (days) | 1.20 | 1.07 | 1.34 | <0.01 |
| Initiation of chemoprophylaxis within 72 hours | 0.33 | 0.09 | 1.21 | 0.09 |
| Injury Severity Score | 1.03 | 0.97 | 1.09 | 0.33 |
| Shock Index | 0.92 | 0.13 | 6.64 | 0.93 |
| Transfused in initial 24 hours | 3.00 | 0.46 | 19.75 | 0.25 |
| Area under ROC curve=0.88 |
PA-Platelet aggregation in aggregation units (AUC), ADP- adenosine diphosphate, delta-change in platelet aggregation from 0 to 24 hours, CK-LY30-percent clot lysis at 30 minutes, shock index-heart rate/systolic blood pressure on arrival