Table 4.

Proposed relative importance of the confidence criteria in the scheme for the assessment of structural alerts relating to acceptable levels of confidence. In this case, the attributes are for hazard identification supporting risk assessment.

Criteria	Comment
Essential Attributes of a Structural Alert – Must be Associated with High Confidence (where possible)
Structural Description	The alert must be explicitly defined in terms of its chemical structure, structural domain and which species it is relevant to.
Property Domain
Toxicity or Relationship to Adversity
Species Specificity
Corroborating Evidence
Desirable Attributes of a Structural Alert – Preferably Associated with High Confidence (where possible)
Metabolic Domain	The mechanistic and metabolic relevance of an alert increases its transparency and potential acceptance.
Mechanistic Interpretation
Mechanistic Causality
Optional Attributes of a Structural Alerts – Where Possible Associated with High/Moderate Confidence
Purpose	Statistical analysis and source data increase the credibility, or otherwise, of a structural alert.
Coverage
Performance
Supporting Evidence