Table 5.

Ideal levels of confidence and characteristics of structural alerts in different use case scenarios. The ideal levels of confidence are defined in Table 3.

Criteria	Hazard Identification Supporting Risk Assessment	Mechanism-Based Analogue Identification	Category Identification e.g., Chemical Class-Based Analogue for HPV Chemicals	Predictions Leading to Classification and Labelling	Screening and/or Prioritisation
Structural Description	High	High	High	High	High
Property Domain	High	High	High	Moderate	Moderate
Toxicity or Relationship to Adversity	High	High	High	High	High
Species Specificity	High	High	High	High	Moderate
Metabolic Domain	High/Moderate	High/Moderate	High/Moderate	Moderate	Moderate
Purpose	High	High	Moderate	Moderate	Moderate
Mechanistic Interpretation	High	High	High	High	High
Mechanistic Causality	High	High	Moderate/High	Moderate/High	Moderate/High
Coverage	High	High	Low	Low	Low
Performance	High	High	Moderate	Moderate	Moderate
Corroborating Evidence	High	High	Moderate	Moderate	Moderate
Supporting Evidence	Moderate	Moderate	Moderate/Low	Low	Low