Table 3.
Low- and Moderate-Dose Aspirin Use and Risk of Incident Persistent Tinnitus Among Women in the Nurses’ Health Study II (2001–2017), Stratified by Age
| Aspirin use (days/week) | Age < 60 years | Age ≥ 60 years | ||
|---|---|---|---|---|
| # of cases | MVHR* (95% CI) | # of cases | MVHR* (95% CI) | |
| Low dose | ||||
| <1 | 4,815 | 1.00 (ref) | 1,667 | 1.00 (ref) |
| 1 | 80 | 1.24 (0.99,1.55) | 41 | 1.10 (0.81,1.51) |
| 2–3 | 121 | 0.98 (0.82,1.18) | 101 | 1.18 (0.96,1.44) |
| 4–5 | 130 | 0.93 (0.78,1.11) | 79 | 0.88 (0.70,1.10) |
| 6–7 | 912 | 1.03 (0.96,1.11) | 692 | 0.91 (0.83,0.99) |
| p-trend | 0.6 | 0.02 | ||
| p-interaction = 0.002 | ||||
| Moderate dose | ||||
| <1 | 5,527 | 1.00 (ref) | 2,381 | 1.00 (ref) |
| 1 | 147 | 1.02 (0.87,1.21) | 56 | 0.95 (0.73,1.24) |
| 2–3 | 158 | 1.07 (0.91,1.25) | 54 | 1.01 (0.77,1.32) |
| 4–5 | 73 | 1.04 (0.82,1.31) | 28 | 0.96 (0.66,1.40) |
| 6–7 | 268 | 1.16 (1.03,1.32) | 116 | 0.92 (0.76,1.11) |
| p-trend | 0.02 | 0.4 | ||
| p-interaction = 0.003 | ||||
*MVHR adjusted for age, race, body mass index, waist circumference, physical activity, smoking, Alternative Health Eating Index (AHEI) score, caffeine intake, hypertension, diabetes, anxiety, depression, rheumatoid arthritis, systemic lupus erythematosus, other arthritis, migraine headache, hearing loss, rheumatoid arthritis, systemic lupus erythematosus, other arthritis, migraine headache, and frequency of use of the other analgesics
Information on analgesic use and time-varying covariates was updated at the beginning of each time period based on information obtained from the most recent questionnaire cycle
MVHR (95% CI)multivariable-adjusted hazard ratio (95% confidence interval)