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. 2022 Oct 7;10:1019063. doi: 10.3389/fbioe.2022.1019063

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Copyright © 2022 Ti, Yang, Chen, Zhang, Xia, Lv, Xiao, Wang and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Soluble factors secreted by CBMSCs and ASCs in the conditioned medium were analyzed using protein chips. (A) Relative concentration of 507 proteins in HEF-CM, ASC-CM, and CBMSC-CM is shown in a heat map. (B) Gene Ontology (GO) function enrichment analysis of biological processes of CBMSC-CM vs. ASC-CM. (C) KEGG signaling pathway enrichment analysis of CBMSC-CM vs. ASC-CM. Heat map of differentially expressed neurotrophic factors (D) and matrix metalloproteinases (E) in CBMSC-CM vs. ASC-CM. See also Supplementary Tables S1–S3. hEF, CBMSC, and ASC represent the CMs of these cells.