TABLE 2.

Summary of commonly used hepatoma cell lines.

Cell line	Metabolic enzymes	Application	References
PHH	Complete hepatocyte metabolic enzyme system	In vitro drug metabolism studies	Zeilinger et al. (2016)
HepG2	Lower levels of liver-specific drug-metabolizing enzymes and transcription factors	Hepatocyte metabolism studies	Zhu et al. (2016)
HepaRG	CYP1A2, CYP2B6, CYP2C9, CYP2E1, CYP3A4, NR, CAR and PXR	In vitro drug metabolism studies	Zanelli et al. (2012)
Huh7	Produces some cytoplasmic proteins, but lacks some metabolic enzymes	In vitro hepatotoxicity and endogenous compound metabolism studies	Feng et al. (2018)