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Crystal structures of pfGRP78-NBD bound with eight nucleoside analogues. (A) DMSO-driven Crystal-ligand replacement assay schematic. (B) Protein-ligand complex structures of pfGRP78-NBD with nucleoside analogues (HP2, HP3, HP5, HP10, HP19, HP20, HP22 and HP23) and corresponding electron density maps contoured to 2F o -F c at the 1 σ level showing molecular replacement of 8-bromoadenosine at the active site of pfGRP78-NBD.
