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. 2022 Oct 7;13:926491. doi: 10.3389/fendo.2022.926491

Table 5.

Histopathological outcomes of all specimens.

All specimens Resection specimen FNA
PanNET 131 (89.1%)* 106 (96.4%)* 25 (67.6%)
Normal pancreas 6 (4.1%) 2 (1.8%) 4 (10.8%)
PDAC 7 (4.8%)*|^ 2 (1.8%)* 5 (13.5%)|^
Other or not representative 3 (2.0%) 0 (0%) 3 (8.1%)

All tissues were collected indicating that patients could contribute multiple specimens; with regards to FNA, three patients had two biopsies of the same lesion. In one patient, the FNA was positive for a PanNET twice; in one, normal pancreatic tissue was followed by PanNET; and in the last patient, the biopsy was positive for PDAC twice. One patient had FNA of two lesions, so the 37 FNA results represent 34 lesions from 22 patients.

*In one patient, the tumor was a collision tumor consisting of a PDAC surrounded by multiple PanNETs.

|In one patient, a biopsy was initially positive for PDAC; revision of the specimen during follow-up changed the conclusion into a PanNET.

^In one patient with a PDAC-positive biopsy, the surgical resection specimen revealed a PanNET and no PDAC.

FNA, fine needle aspiration; PDAC, pancreatic ductal adenocarcinoma; PanNET, pancreatic neuroendocrine tumor.