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. 2022 Oct 7;13:974715. doi: 10.3389/fphar.2022.974715

TABLE 2.

SeDeM Parameters, indices, limit values and calculating factors.

Incidence Parameters Limit value (v) Factors applied to v Radius (r)
Dimension Bulk density (Da) 0–1 g/ml 10v 0–10
Tapped density (Dc) 0–1 g/ml 10v 0–10
Compressibility Inter-particle porosity (Ie) 0–1.2 10v/1.2 0–10
Carr’s index (IC) 0–50 (%) v/5 0–10
Cohesion index (Icd) 0–200 (N) v/20 0–10
Flowability/powder flow Hausner’s ratio (IH) 1–3 5 (3 - v) 0–10
Angle of repose (α) 50–0 (°) 10 - (v/5) 0–10
Powder flow (tn) 20–0 (s) 10 - (v/2) 0–10
Lubricity/Stability Loss on drying (% HR) 0–10 (%) 10 - v 0–10
Hygroscopicity (% H) 20–0 (%) 10 - (v/2) 0–10
Lubricity/dosage Particle size (% Pf) 50–0 (%) 10 - (v/5) 0–10
Homogeneity index (Iθ) 0–2 × 10–2 500v 0–10