TABLE 4.

Composition of tramadol HCl formulations.

Formulations code	Tramadol HCl		Avicel pH 101®		Sodium chloride		Methocel™ K4M		Magnesium stearate		Aerosil™ 200		Tablet Weight	Coating gain	Orifice size
	Drug		Filler/Binder		Osmogen		Release retardant		Lubricant		Glidant
	mg	%	mg	%	mg	%	mg	%	mg	%	mg	%	mg	%	mm
F1	190	38	230	46	20	4	50	10	7.5	1.5	2.5	0.5	500	8	0.2
F2	190	38	230	46	20	4	50	10	7.5	1.5	2.5	0.5	500	8	0.8
F3	190	38	230	46	20	4	50	10	7.5	1.5	2.5	0.5	500	12	0.2
F4	190	38	230	46	20	4	50	10	7.5	1.5	2.5	0.5	500	12	0.8
F5	190	38	210	42	40	8	50	10	7.5	1.5	2.5	0.5	500	8	0.2
F6	190	38	210	42	40	8	50	10	7.5	1.5	2.5	0.5	500	8	0.8
F7	190	38	210	42	40	8	50	10	7.5	1.5	2.5	0.5	500	12	0.2
F8	190	38	210	42	40	8	50	10	7.5	1.5	2.5	0.5	500	12	0.8
F9	190	38	180	36	20	4	100	20	7.5	1.5	2.5	0.5	500	8	0.2
F10	190	38	180	36	20	4	100	20	7.5	1.5	2.5	0.5	500	8	0.8
F11	190	38	180	36	20	4	100	20	7.5	1.5	2.5	0.5	500	12	0.2
F12	190	38	180	36	20	4	100	20	7.5	1.5	2.5	0.5	500	12	0.8
F13	190	38	160	32	40	8	100	20	7.5	1.5	2.5	0.5	500	8	0.2
F14	190	38	160	32	40	8	100	20	7.5	1.5	2.5	0.5	500	8	0.8
F15	190	38	160	32	40	8	100	20	7.5	1.5	2.5	0.5	500	12	0.2
F16	190	38	160	32	40	8	100	20	7.5	1.5	2.5	0.5	500	12	0.8