. 2022 Oct 7;13:974715. doi: 10.3389/fphar.2022.974715

TABLE 6.

The release rate and coefficient of correlation of tramadol osmotic formulations calculated by Model Dependent Kinetics.

Formulations code	First order		Zero order		Higuchi		Korsmeyer-Peppas			Hixon-Crowell		Baker-lonsdale		Weibull

	r²	k₁	r²	k_o	r²	k_H	r²	n	k_KP	r²	k_HC	r²	k_BL	r²	α	β
	r²	(hr ⁻¹ )	r²	(hr ⁻¹ )	r²	(hr ^−1/2 )	r²	n	(hr. ^-n )	r²	(hr ^−1/3 )	r²	(hr ⁻¹ )	r²	α	β
F1	0.978	0.101	0.656	4.717	0.964	19.655	0.965	0.476	20.977	0.95	0.03	0.96	0.011	0.998	7.426	0.931
F2	0.929	0.139	0.562	6.423	0.98	22.03	0.993	0.42	26.371	0.98	0.033	0.943	0.011	0.993	3.844	0.675
F3	0.97	0.097	0.992	5.898	0.90	19.146	0.999	0.897	8.098	0.989	0.028	0.843	0.008	0.992	20.375	1.313
F4	0.962	0.097	0.994	6.271	0.959	20.308	0.997	0.902	8.02	0.977	0.031	0.826	0.009	0.984	22.609	1.407
F5	0.994	0.374	0.482	12.521	0.959	34.157	0.986	0.382	42.046	0.969	0.102	0.992	0.037	0.999	2.295	0.859
F6	0.994	0.389	0.457	12.651	0.954	34.561	0.986	0.373	42.213	0.971	0.106	0.993	0.039	0.999	2.217	0.86
F7	0.969	0.226	0.489	8.333	0.962	26.868	0.986	0.396	33.464	0.916	0.061	0.992	0.021	0.998	3.044	0.752
F8	0.964	0.238	0.522	9.419	0.971	28.069	0.99	0.402	33.982	0.907	0.064	0.994	0.022	0.997	2.857	0.734
F9	0.901	0.135	0.988	8.37	0.822	23.074	0.99	1.061	7.327	0.937	0.039	0.753	0.012	0.984	34.477	1.821
F11	0.946	0.111	0.989	6.81	0.863	20.499	0.992	0.951	7.643	0.972	0.032	0.802	0.009	0.991	25.13	1.501
F12	0.952	0.114	0.976	6.495	0.889	21.099	0.986	0.858	9.22	0.978	0.032	0.824	0.01	0.991	23.108	1.464
F13	0.92	0.129	0.985	7.498	0.87	22.644	0.988	0.929	8.856	0.953	0.037	0.798	0.012	0.967	23.425	1.553
F14	0.92	0.132	0.982	7.568	0.876	22.907	0.986	0.906	9.422	0.952	0.037	0.804	0.012	0.962	20.988	1.511
F15	0.894	0.081	0.978	5.475	0.78	17.266	0.992	1.229	3.095	0.925	0.024	0.723	0.006	0.979	77.28	1.806
F16	0.895	0.082	0.981	5.489	0.788	17.362	0.994	1.22	3.174	0.925	0.024	0.731	0.006	0.975	76.775	1.802