Table 1.

Common NSAID dosing

Medication	Starting Dose	Usual Dosing Range	Other
Aspirin	325 mg 3 times a day	325–650 mg 4 times a day	Doses of 3600 mg/d are needed for anti-inflammatory activity
Celecoxib	100 mg/d	100 mg twice daily or 200 mg/d
Diclofenac XR Diclofenac IR	100 mg/d 50 mg twice a day	100–200 mg/d 50–75 mg twice a day
Etodolac	300 mg twice a day	400–500 mg twice a day
Ibuprofen	200 mg 3 times a day	1200–3200 mg/d in 3 to 4 divided doses	Available OTC and Rx
Indomethacin Indomethacin SR	25 mg twice a day 75 mg SR once daily	Titrate dose by 25–50 mg/d until pain controlled or maximum dose of 50 mg 3 times a day Can titrate to 75 mg SR twice daily if needed
Ketoprofen	50 mg 3 times a day	50–75 mg 3 to 4 times a day
Meloxicam	7.5 mg/d	15 mg/d
Naproxen	250 mg twice a day	500 mg twice a day	Available OTC and Rx
Naproxen sodium Naproxen sodium CR	220 mg twice a day	220–550 mg twice a day 375–750 mg twice a day
Salsalate	500 mg twice a day	500–1000 mg 2 to 3 times a day

Abbreviations: CR, controlled release; IR, immediate release; OTC, over-the-counter; Rx, prescription; SR, sustained release; XR, extended release.

Data from Buys LM, Wiedenfeld SA. Osteoarthritis. In: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey L. eds. Pharmacotherapy: A Pathophysiologic Approach, 10e. McGraw-Hill; Accessed October 06, 2020. https://accesspharmacy.mhmedical.com/content.aspx?bookid=1861&sectionid=133893029.